• Human Thrombospondin-1/THBS1 protein (Recombinant) (C-His) (STJP001211)

Human Thrombospondin-1/THBS1 protein (Recombinant) (C-His) (STJP001211)

SKU:
STJP001211

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human Thrombospondin-1/THBS1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Gene Symbol: THBS1
Gene ID: 7057
Uniprot ID: TSP1_HUMAN
Immunogen: Recombinant Human Thrombospondin-1/THBS1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asn19-Pro1170) of human Thrombospondin-1 (Accession #NP_003237.2) fused with a 8×His tag at the C-terminus.
Function Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47. Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure. Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS. Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. Negatively modulates wound healing, acting via CD47. Ligand for receptor CD36. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36. Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47. Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner. Ligand for immunoglobulin-like cell surface receptor SIRPA. Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA. Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity.its effects may be mediated, at least in part, through enhanced adipocyte proliferation. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors. May be involved in age-related conditions, including metabolic dysregulation, during normal aging.
Protein Name Thrombospondin-1
Glycoprotein G
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-186797
Reactome: R-HSA-216083
Reactome: R-HSA-3000170
Reactome: R-HSA-5083635
Reactome: R-HSA-5173214
Reactome: R-HSA-8936459
Cellular Localisation Secreted
Cell Surface
Extracellular Space
Extracellular Matrix
Endoplasmic Reticulum
Sarcoplasmic Reticulum
Secreted By Thrombin-Activated Platelets And Binds To The Cell Surface In The Presence Of Extracellular Ca(2+)
Incorporated Into The Extracellular Matrix (Ecm) Of Fibroblasts
The C-Terminal Region In Trimeric Form Is Required For Retention In The Ecm
Also Detected In The Endoplasmic Reticulum And Sarcoplasmic Reticulum Where It Plays A Role In The Er Stress Response
Alternative Protein Names Thrombospondin-1 protein
Glycoprotein G protein
THBS1 protein
TSP protein
TSP1 protein

Information sourced from Uniprot.org

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