| Short Description : | Recombinant-Human Thrombopoietin/THPO-C-His protein was developed in hek293 cells using the region Ser22-Gly353. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | 1.Recombinant Human TPO (50 ng/mL) , IL-3 (15 ng/mL, Cat. RP01362) , IL-6 (15 ng/mL, Cat. RP00201) and IL-11 (15 ng/mL, Cat. RP00050) induce hematopoietic stem and progenitor cells to differentiate into megakaryocytes. After 6 days, the induction of |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | THPO |
| Gene ID: | 7066 |
| Uniprot ID: | TPO_HUMAN |
| Immunogen: | Recombinant Human Thrombopoietin/THPO Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser22-Gly353) of human Thrombopoietin/THPO (Accession #NP_000451.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Ser22-Gly353 |
| Immunogen Sequence: | SPAPPACDLRVLSKLLRDSH VLHSRLSQCPEVHPLPTPVL LPAVDFSLGEWKTQMEETKA QDILGAVTLLLEGVMAARGQ LGPTCLSSLLGQLSGQVRLL LGALQSLLGTQLPPQGRTTA HKDPNAIFLSFQHLLRGKVR FLMLVGGSTLCVRRAPPTTA VPSRTSLVLTLNELPNRTSG LLETNFTASARTTGSGLLKW QQGFRAKIPGLLNQTSRSLD QIPGYLNRIHELLNGTRGL |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Protein Name | ThrombopoietinC-Mpl LigandMlMegakaryocyte Colony-Stimulating FactorMegakaryocyte Growth And Development FactorMgdfMyeloproliferative Leukemia Virus Oncogene Ligand |
| Database Links | Reactome: R-HSA-76009 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Thrombopoietin proteinC-Mpl Ligand proteinMl proteinMegakaryocyte Colony-Stimulating Factor proteinMegakaryocyte Growth And Development Factor proteinMgdf proteinMyeloproliferative Leukemia Virus Oncogene Ligand proteinTHPO proteinMGDF protein |
Information sourced from Uniprot.org
