Human Thrombopoietin R/MPL/CD110 protein (Recombinant) (C-His) (STJP020353)

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STJP020353-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: MPL
Gene ID: 4352
Uniprot ID: TPOR_HUMAN
Immunogen Region: Gln26-Trp491
Immunogen: Recombinant Human Thrombopoietin R/MPL/CD110 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Trp491) of human Thrombopoietin R/MPL (Accession #NP_005364.1) fused with a 6×His tag at the C-te
Immunogen Sequence: QDVSLLASDSEPLKCFSRTF EDLTCFWDEEEAAPSGTYQL LYAYPREKPRACPLSSQSMP HFGTRYVCQFPDQEEVRLFF PLHLWVKNVFLNQTRTQRVL FVDSVGLPAPPSIIKAMGGS QPGELQISWEEPAPEISDFL RYELRYGPRDPKNSTGPTVI QLIATETCCPALQRPHSASA LDQSPCAQPTMPWQDGPKQT SPSREASALTAEGGSCLISG LQPGNSYWLQLRSEPDGIS
Tissue Specificity Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
Post Translational Modifications Phosphorylated at Tyr-591 in response to THPO stimulation. Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
Function Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.
Protein Name Thrombopoietin Receptor
Tpo-R
Myeloproliferative Leukemia Protein
Proto-Oncogene C-Mpl
Cd Antigen Cd110
Database Links Reactome: R-HSA-76009
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cell Surface
Alternative Protein Names Thrombopoietin Receptor protein
Tpo-R protein
Myeloproliferative Leukemia Protein protein
Proto-Oncogene C-Mpl protein
Cd Antigen Cd110 protein
MPL protein
TPOR protein

Information sourced from Uniprot.org

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