| Host: | Rabbit/Rabbit |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | This Thrombomodulin antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Clonality : | Monoclonal/Monoclonal |
| Clone ID : | R01-4F4/R08-5H0 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.2 |
| Purification: | Affinity Purified |
| Concentration: | 1 mg/mL |
| Dilution Range: | Determined by end user |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | THBD |
| Gene ID: | 7056 |
| Uniprot ID: | TRBM_HUMAN |
| Immunogen: | Recombinant protein of human Thrombomodulin |
| Tissue Specificity | Endothelial cells are unique in synthesizing thrombomodulin. |
| Post Translational Modifications | N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response. |
| Protein Name | ThrombomodulinTmFetomodulinCd Antigen Cd141 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Thrombomodulin antibody pairTm antibody pairFetomodulin antibody pairCd Antigen Cd141 antibody pairTHBD antibody pairTHRM antibody pair |
Information sourced from Uniprot.org
![Anti-Thrombomodulin antibody [1009] (STJ16100458)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/149175/346800/STJ16100458_1__09195.1681998903.jpg?c=1 "Anti-Thrombomodulin antibody [1009] (STJ16100458)")
