SDS-PAGE gel of recombinant human THG1L protein under reducing conditions with Coomassie blue stain

Human THG1L protein (Recombinant) (His-Tag) (STJP017777)

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STJP017777
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Short Description :Recombinant-Human THG1L-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:THG1L
Gene ID:54974
Uniprot ID:THG1_HUMAN
Accession Number:NP_060342
Immunogen:Human
Immunogen Region:30-298aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAKSKFE YVRDFEADDT CLAHCWVVVR LDGRNFHRFA EKHNFAKPND SRALQLMTKC AQTVMEELED IVIAYGQSDE YSFVFKRKTN WFKRRASKFM THVASQFASS YVFYWRDYFE DQPLLYPPGF DGRVVVYPSN QTLKDYLSWR QADCHINNLY NTVFWALIQQ SGLTPVQAQG RLQGTLAADK NEILFSEFNI NYNNELPM
Tissue Specificity Expressed in many tissues.
Function Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.
Protein Name Probable Trna(His Guanylyltransferase
Induced In High Glucose-1
Ihg-1
Interphase Cytoplasmic Foci Protein 45
Trna-Histidine Guanylyltransferase
Database Links Reactome: R-HSA-6782315
Cellular Localisation Cytoplasm
Mitochondrion Outer Membrane
Alternative Protein Names Probable Trna(His Guanylyltransferase protein
Induced In High Glucose-1 protein
Ihg-1 protein
Interphase Cytoplasmic Foci Protein 45 protein
Trna-Histidine Guanylyltransferase protein
THG1L protein
ICF45 protein

Information sourced from Uniprot.org

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