| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human THAP1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | THAP1 |
| Gene ID: | 55145 |
| Uniprot ID: | THAP1_HUMAN |
| Immunogen Region: | Ser21-Glu66 |
| Immunogen: | Homo sapiens (Human) |
| Function | DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
| Protein Name | Thap Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasmPml Body |
| Alternative Protein Names | Thap Domain-Containing Protein 1 proteinTHAP1 protein |
Information sourced from Uniprot.org