Human THAP1 protein (Recombinant) (N-GST & C-His) (STJP010964)

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STJP010964
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human THAP1-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: THAP1
Gene ID: 55145
Uniprot ID: THAP1_HUMAN
Immunogen Region: Ser21-Glu66
Immunogen: Homo sapiens (Human)
Function DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Protein Name Thap Domain-Containing Protein 1
Cellular Localisation Nucleus
Nucleoplasm
Pml Body
Alternative Protein Names Thap Domain-Containing Protein 1 protein
THAP1 protein

Information sourced from Uniprot.org