| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK (Dnp)-NH2. The IC50 value is <0.41 nM. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | TFPI |
| Gene ID: | 7035 |
| Uniprot ID: | TFPI1_HUMAN |
| Immunogen: | Recombinant Human TFPI Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp29-Lys282) of human TFPI1 (Accession #NP_006278.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Asp29-Lys282 |
| Immunogen Sequence: | DSEEDEEHTIITDTELPPLK LMHSFCAFKADDGPCKAIMK RFFFNIFTRQCEEFIYGGCE GNQNRFESLEECKKMCTRDN ANRIIKTTLQQEKPDFCFLE EDPGICRGYITRYFYNNQTK QCERFKYGGCLGNMNNFETL EECKNICEDGPNGFQVDNYG TQLNAVNNSLTPQSTKVPSL FEFHGPSWCLTPADRGLCRA NENRFYYNSVIGKCRPFKYS GCGGNENNFTSKQECLRAC |
| Post Translational Modifications | O-glycosylated. |
| Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
| Protein Name | Tissue Factor Pathway InhibitorTfpiExtrinsic Pathway InhibitorEpiLipoprotein-Associated Coagulation InhibitorLaci |
| Database Links | Reactome: R-HSA-140834 |
| Cellular Localisation | Isoform Alpha: SecretedIsoform Beta: Microsome MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Tissue Factor Pathway Inhibitor proteinTfpi proteinExtrinsic Pathway Inhibitor proteinEpi proteinLipoprotein-Associated Coagulation Inhibitor proteinLaci proteinTFPI proteinLACI proteinTFPI1 protein |
Information sourced from Uniprot.org
