Human TFDP1 protein (Recombinant) (N-GST) (STJP005387)

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STJP005387
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TFDP1-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TFDP1
Gene ID: 7027
Uniprot ID: TFDP1_HUMAN
Immunogen Region: Gly6-Asp410
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.
Function Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTCCGCGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.
Protein Name Transcription Factor Dp-1
Drtf1-Polypeptide 1
Drtf1
E2f Dimerization Partner 1
Database Links Reactome: R-HSA-111448
Reactome: R-HSA-113501
Reactome: R-HSA-1362277
Reactome: R-HSA-1362300
Reactome: R-HSA-139915
Reactome: R-HSA-1538133
Reactome: R-HSA-1912408
Reactome: R-HSA-2173796
Reactome: R-HSA-2559580
Reactome: R-HSA-2559585
Reactome: R-HSA-6804114
Reactome: R-HSA-69202
Reactome: R-HSA-69205
Reactome: R-HSA-69231
Reactome: R-HSA-69656
Reactome: R-HSA-8953750
Reactome: R-HSA-9616222
Reactome: R-HSA-9661069
Cellular Localisation Nucleus
Cytoplasm
Shuttles Between The Cytoplasm And Nucleus And Translocates Into The Nuclear Compartment Upon Heterodimerization With E2f1
Alternative Protein Names Transcription Factor Dp-1 protein
Drtf1-Polypeptide 1 protein
Drtf1 protein
E2f Dimerization Partner 1 protein
TFDP1 protein
DP1 protein

Information sourced from Uniprot.org