Human TFAM protein (Recombinant) (N-GST) (STJP005108)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human TFAM-N-GST protein was developed from e.coli for the region N-GST. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | TFAM |
| Gene ID | 7019 |
| Uniprot ID | TFAM_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser43-Cys246 |
Additional Info
| Function | Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. |
| Protein Name | Transcription Factor A - MitochondrialMttfaMitochondrial Transcription Factor 1Mttf1Transcription Factor 6Tcf-6Transcription Factor 6-Like 2 |
| Database Links | Reactome: R-HSA-163282Reactome: R-HSA-2151201Reactome: R-HSA-9837999 |
| Cellular Localisation | MitochondrionMitochondrion MatrixMitochondrion Nucleoid |
| Alternative Protein Names | Transcription Factor A - Mitochondrial proteinMttfa proteinMitochondrial Transcription Factor 1 proteinMttf1 proteinTranscription Factor 6 proteinTcf-6 proteinTranscription Factor 6-Like 2 proteinTFAM proteinTCF6 proteinTCF6L2 protein |
Information sourced from Uniprot.org