Human TFAM protein (Recombinant) (N-GST) (STJP005108)

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STJP005108
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TFAM-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TFAM
Gene ID: 7019
Uniprot ID: TFAM_HUMAN
Immunogen Region: Ser43-Cys246
Immunogen: Homo sapiens (Human)
Function Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Protein Name Transcription Factor A - Mitochondrial
Mttfa
Mitochondrial Transcription Factor 1
Mttf1
Transcription Factor 6
Tcf-6
Transcription Factor 6-Like 2
Database Links Reactome: R-HSA-163282
Reactome: R-HSA-2151201
Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion
Mitochondrion Matrix
Mitochondrion Nucleoid
Alternative Protein Names Transcription Factor A - Mitochondrial protein
Mttfa protein
Mitochondrial Transcription Factor 1 protein
Mttf1 protein
Transcription Factor 6 protein
Tcf-6 protein
Transcription Factor 6-Like 2 protein
TFAM protein
TCF6 protein
TCF6L2 protein

Information sourced from Uniprot.org

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