Human TESC protein (Recombinant) (N-His) (STJP008273)

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STJP008273
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human TESC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: TESC
Gene ID: 54997
Uniprot ID: CHP3_HUMAN
Immunogen Region: Met1-His214
Immunogen: Homo sapiens (Human)
Function Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Protein Name Calcineurin B Homologous Protein 3
Tescalcin
Tsc
Cellular Localisation Nucleus
Cytoplasm
Membrane
Lipid-Anchor
Cell Membrane
Cell Projection
Lamellipodium
Ruffle Membrane
Colocalizes With Slc9a1 At The Plasma Membrane
Alternative Protein Names Calcineurin B Homologous Protein 3 protein
Tescalcin protein
Tsc protein
TESC protein
CHP3 protein

Information sourced from Uniprot.org

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