Human TEM8/ANTXR1 protein (Recombinant) (C-His) (STJP002702)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human TEM8/ANTXR1 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Glu33-Lys321) of human ANTXR1 (Accession #Q9H6X2) fused with a 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human TEM8/ANTXR1-C-His protein was developed in hek293 cells using the region Glu33-Lys321. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.01 EU/ug of the protein by LAL method |
Target Information
| Gene Symbol | ANTXR1 |
| Gene ID | 84168 |
| Uniprot ID | ANTR1_HUMAN |
| Immunogen | Recombinant Human TEM8/ANTXR1 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Glu33-Lys321) of human ANTXR1 (Accession #Q9H6X2) fused with a 6×His tag at the C-terminus. |
| Immunogen Region | Glu33-Lys321 |
| Immunogen Sequence | EDGGPACYGGFDLYFILDKS GSVLHHWNEIYYFVEQLAHK FISPQLRMSFIVFSTRGTTL MKLTEDREQIRQGLEELQKV LPGGDTYMHEGFERASEQIY YENRQGYRTASVIIALTDGE LHEDLFFYSEREANRSRDLG AIVYCVGVKDFNETQLARIA DSK |
Additional Info
| Post Translational Modifications | Glycosylated. Glycosylation is essential for Seneca Valley virus (SVV) attachment and entry. Phosphorylated upon PLAU binding. |
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated. |
| Protein Name | Anthrax Toxin Receptor 1Tumor Endothelial Marker 8 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionLamellipodium MembraneFilopodium MembraneAt The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched FilopodiaColocalizes With Actin At The Base Of Lamellipodia |
| Alternative Protein Names | Anthrax Toxin Receptor 1 proteinTumor Endothelial Marker 8 proteinANTXR1 proteinATR proteinTEM8 protein |
Information sourced from Uniprot.org