Human TEM8/ANTXR1 protein (Recombinant) (C-His) (STJP002702)

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STJP002702
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/ug of the protein by LAL method
Gene Symbol: ANTXR1
Gene ID: 84168
Uniprot ID: ANTR1_HUMAN
Immunogen Region: Glu33-Lys321
Immunogen: Recombinant Human TEM8/ANTXR1 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Glu33-Lys321) of human ANTXR1 (Accession #Q9H6X2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: EDGGPACYGGFDLYFILDKS GSVLHHWNEIYYFVEQLAHK FISPQLRMSFIVFSTRGTTL MKLTEDREQIRQGLEELQKV LPGGDTYMHEGFERASEQIY YENRQGYRTASVIIALTDGE LHEDLFFYSEREANRSRDLG AIVYCVGVKDFNETQLARIA DSK
Post Translational Modifications Glycosylated. Glycosylation is essential for Seneca Valley virus (SVV) attachment and entry. Phosphorylated upon PLAU binding.
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated.
Protein Name Anthrax Toxin Receptor 1
Tumor Endothelial Marker 8
Database Links Reactome: R-HSA-5210891
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Lamellipodium Membrane
Filopodium Membrane
At The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched Filopodia
Colocalizes With Actin At The Base Of Lamellipodia
Alternative Protein Names Anthrax Toxin Receptor 1 protein
Tumor Endothelial Marker 8 protein
ANTXR1 protein
ATR protein
TEM8 protein

Information sourced from Uniprot.org

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