| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.01 EU/ug of the protein by LAL method |
| Gene Symbol: |
ANTXR1 |
| Gene ID: |
84168 |
| Uniprot ID: |
ANTR1_HUMAN |
| Immunogen Region: |
Glu33-Lys321 |
| Immunogen: |
Recombinant Human TEM8/ANTXR1 Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Glu33-Lys321) of human ANTXR1 (Accession #Q9H6X2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
EDGGPACYGGFDLYFILDKS GSVLHHWNEIYYFVEQLAHK FISPQLRMSFIVFSTRGTTL MKLTEDREQIRQGLEELQKV LPGGDTYMHEGFERASEQIY YENRQGYRTASVIIALTDGE LHEDLFFYSEREANRSRDLG AIVYCVGVKDFNETQLARIA DSK |
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. |
| Protein Name | Anthrax Toxin Receptor 1Tumor Endothelial Marker 8 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionLamellipodium MembraneFilopodium MembraneAt The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched FilopodiaColocalizes With Actin At The Base Of Lamellipodia |
| Alternative Protein Names | Anthrax Toxin Receptor 1 proteinTumor Endothelial Marker 8 proteinANTXR1 proteinATR proteinTEM8 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
