| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human TCF7-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | TCF7 |
| Gene ID: | 6932 |
| Uniprot ID: | TCF7_HUMAN |
| Immunogen Region: | Lys270-Gln354 |
| Immunogen: | Homo sapiens (Human) |
| Function | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. |
| Protein Name | Transcription Factor 7Tcf-7T-Cell-Specific Transcription Factor 1T-Cell Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9754189Reactome: R-HSA-9796292Reactome: R-HSA-9825892 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Transcription Factor 7 proteinTcf-7 proteinT-Cell-Specific Transcription Factor 1 proteinT-Cell Factor 1 proteinTcf-1 proteinTCF7 proteinTCF1 protein |
Information sourced from Uniprot.org