| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | SDC1 |
| Gene ID: | 6382 |
| Uniprot ID: | SDC1_HUMAN |
| Immunogen: | Recombinant Human Syndecan-1/SDC1/CD138 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln23-Glu251) of human Syndecan-1/SDC1/CD138 (Accession #NP_001006947.1) fused with a raFc tag at the C-term |
| Immunogen Sequence: | QIVATNLPPEDQDGSGDDSD NFSGSGAGALQDITLSQQTP STWKDTQLLTAIPTSPEPTG LEATAASTSTLPAGEGPKEG EAVVLPEVEPGLTAREQEAT PRPRETTQLPTTHLASTTTA TTAQEPATSHPHRDMQPGHH ETSTPAGPSQADLHTPHTED GGPSATERAAEDGASSQLPA AEGSGEQDFTFETSGENTAV VAVEPDRRNQSPVDQGATGA SQGLLDRKE |
| Post Translational Modifications | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. |
| Function | Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway. |
| Protein Name | Syndecan-1 Synd1 Cd Antigen Cd138 |
| Database Links | Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-202733 Reactome: R-HSA-3000170 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-449836 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Secreted Extracellular Exosome Shedding Of The Ectodomain Produces A Soluble Form |
| Alternative Protein Names | Syndecan-1 protein Synd1 protein Cd Antigen Cd138 protein SDC1 protein SDC protein |
Information sourced from Uniprot.org