Human Sulfotransferase 2A1/SULT2A1 protein (Recombinant) (His-Tag) (STJP017218)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Sulfotransferase 2A1/SULT2A1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SULT2A1 |
| Gene ID | 6822 |
| Uniprot ID | ST2A1_HUMAN |
| Accession Number | NP_003158 |
| Immunogen | Human |
| Immunogen Region | 1-285aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols. |
| Protein Name | Sulfotransferase 2a1St2a1Bile Salt SulfotransferaseDehydroepiandrosterone SulfotransferaseDhea-StDhea-St8Hydroxysteroid SulfotransferaseHstSt2Sult2a3 |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-1989781Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Sulfotransferase 2a1 proteinSt2a1 proteinBile Salt Sulfotransferase proteinDehydroepiandrosterone Sulfotransferase proteinDhea-St proteinDhea-St8 proteinHydroxysteroid Sulfotransferase proteinHst proteinSt2 proteinSult2a3 proteinSULT2A1 proteinHST proteinSTD protein |
Information sourced from Uniprot.org