| Function | Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis. |
| Protein Name | Succinyl-Coa -Glutarate Coa-TransferaseDermal Papilla-Derived Protein 13Dicarboxyl-Coa -Dicarboxylic Acid Coenzyme A Transferase SugctSuccinate--Hydroxymethylglutarate Coa-Transferase |
| Database Links | |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Succinyl-Coa -Glutarate Coa-Transferase proteinDermal Papilla-Derived Protein 13 proteinDicarboxyl-Coa -Dicarboxylic Acid Coenzyme A Transferase Sugct proteinSuccinate--Hydroxymethylglutarate Coa-Transferase proteinSUGCT proteinC7orf10 proteinDERP13 protein |
Information sourced from Uniprot.org
