SDS-PAGE gel of recombinant human SUB1 protein stained with Coomassie blue

Human SUB1 protein (Recombinant) (His-Tag) (STJP016713)

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STJP016713
£134.50 - £738.50
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Short Description :Recombinant-Human SUB1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 5mM DTT, 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SUB1
Gene ID:10923
Uniprot ID:TCP4_HUMAN
Accession Number:NP_006704.3
Immunogen:Human
Immunogen Region:1-127aa
Immunogen Sequence: MPKSKELVSS SSSGSDSDSE VDKKLKRKKQ VAPEKPVKKQ KTGETSRALS SSKQSSSSRD DNMFQIGKMR YVSVRDFKGK VLIDIREYWM DPEGEMKPGR KGISLNPEQW SQLKEQISDI DDAVRKL
Post Translational Modifications Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
Function General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Protein Name Activated Rna Polymerase Ii Transcriptional Coactivator P15
Positive Cofactor 4
Pc4
Sub1 Homolog
P14
Database Links
Cellular Localisation Nucleus
Alternative Protein Names Activated Rna Polymerase Ii Transcriptional Coactivator P15 protein
Positive Cofactor 4 protein
Pc4 protein
Sub1 Homolog protein
P14 protein
SUB1 protein
PC4 protein
RPO2TC1 protein

Information sourced from Uniprot.org

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