Human STX4 protein (Recombinant) (N-His) (STJP009641)

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STJP009641
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human STX4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: STX4
Gene ID: 6810
Uniprot ID: STX4_HUMAN
Immunogen Region: Ser36-Leu275
Immunogen: Homo sapiens (Human)
Function Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing.
Protein Name Syntaxin-4
Renal Carcinoma Antigen Ny-Ren-31
Database Links Reactome: R-HSA-114516
Reactome: R-HSA-1236974
Reactome: R-HSA-1445148
Reactome: R-HSA-199992
Reactome: R-HSA-449836
Cellular Localisation Cell Membrane
Single-Pass Type Iv Membrane Protein
Cell Projection
Neuron Projection
Stereocilium
Localizes To Neurite Tips In Neuronal Cells
Alternative Protein Names Syntaxin-4 protein
Renal Carcinoma Antigen Ny-Ren-31 protein
STX4 protein
STX4A protein

Information sourced from Uniprot.org

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