| Post Translational Modifications | Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A. |
| Function | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. |
| Protein Name | Stomatin-Like Protein 2 - MitochondrialSlp-2Epb72-Like Protein 2Paraprotein Target 7Paratarg-7 |
| Database Links | Reactome: R-HSA-8949664Reactome: R-HSA-9840373 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMitochondrionMitochondrion Inner MembraneLipid-AnchorMitochondrion Intermembrane SpaceMembrane RaftCytoplasmCytoskeletonBehaves As An Integral Membrane Protein Of The Mitochondrion Despite The Absence Of A Detectable Transmembrane DomainAlso Associates With The Actin Cytoskeleton And Membrane Rafts In Activated T-CellsA Minor Pool Is Associated With The Plasma Membrane And Is Enriched At The Immunological Synapse In Activated T-Cells |
| Alternative Protein Names | Stomatin-Like Protein 2 - Mitochondrial proteinSlp-2 proteinEpb72-Like Protein 2 proteinParaprotein Target 7 proteinParatarg-7 proteinSTOML2 proteinSLP2 proteinHSPC108 protein |
Information sourced from Uniprot.org
