| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human STAM2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | STAM2 |
| Gene ID: | 10254 |
| Uniprot ID: | STAM2_HUMAN |
| Immunogen Region: | Met1-Leu377 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
| Protein Name | Signal Transducing Adapter Molecule 2Stam-2Hrs-Binding Protein |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689880Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Protein Names | Signal Transducing Adapter Molecule 2 proteinStam-2 proteinHrs-Binding Protein proteinSTAM2 proteinHBP protein |
Information sourced from Uniprot.org