| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. |
| Function | A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage. Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets. Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation. Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2. In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively. Metabolizes brain c-series ganglioside GT1c forming GQ1c. Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4Alpha 2 -3-St 4Beta-Galactoside Alpha-2 -3-Sialyltransferase 4Alpha 2 -3-Sialyltransferase IvGal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseGal-Beta-1 -4-Glcnac-Alpha-2 -3-SialyltransferaseN-Acetyllactosaminide Alpha-2 -3-SialyltransferaseSat-3St-4St3gal IvSt3galivSt3gala.2StzSialyltransferase 4cSiat4-C |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9037629Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-975577Reactome: R-HSA-977068 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form In Trans Cisternae Of GolgiSecreted Into The Body Fluid |
| Alternative Protein Names | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 4 proteinAlpha 2 -3-St 4 proteinBeta-Galactoside Alpha-2 -3-Sialyltransferase 4 proteinAlpha 2 -3-Sialyltransferase Iv proteinGal-Nac6s proteinGal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase proteinGal-Beta-1 -4-Glcnac-Alpha-2 -3-Sialyltransferase proteinN-Acetyllactosaminide Alpha-2 -3-Sialyltransferase proteinSat-3 proteinSt-4 proteinSt3gal Iv proteinSt3galiv proteinSt3gala.2 proteinStz proteinSialyltransferase 4c proteinSiat4-C proteinST3GAL4 proteinCGS23 proteinNANTA3 proteinSIAT4C proteinSTZ protein |
Information sourced from Uniprot.org
