| Function | Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. |
| Protein Name | Calcium-Responsive TransactivatorSs18-Like Protein 1Syt Homolog 1 |
| Database Links | Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Nuclear BodiesColocalizes With Sgo1 At Kinetochore |
| Alternative Protein Names | Calcium-Responsive Transactivator proteinSs18-Like Protein 1 proteinSyt Homolog 1 proteinSS18L1 proteinCREST proteinKIAA0693 protein |
Information sourced from Uniprot.org
