Human SRSF10 protein (Recombinant) (N-His) (STJP010736)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SRSF10-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SRSF10 |
| Gene ID | 10772 |
| Uniprot ID | SRS10_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser121 |
Additional Info
| Post Translational Modifications | Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. |
| Function | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 1040 Kda Sr-Repressor ProteinSrrp40Fus-Interacting Serine-Arginine-Rich Protein 1Splicing Factor Srp38Splicing Factor - Arginine/Serine-Rich 13aTls-Associated Protein With Ser-Arg RepeatsTasrTls-Associated Protein With Sr RepeatsTls-Associated Serine-Arginine ProteinTls-Associated Sr Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Protein Names | Serine/Arginine-Rich Splicing Factor 10 protein40 Kda Sr-Repressor Protein proteinSrrp40 proteinFus-Interacting Serine-Arginine-Rich Protein 1 proteinSplicing Factor Srp38 proteinSplicing Factor - Arginine/Serine-Rich 13a proteinTls-Associated Protein With Ser-Arg Repeats proteinTasr proteinTls-Associated Protein With Sr Repeats proteinTls-Associated Serine-Arginine Protein proteinTls-Associated Sr Protein proteinSRSF10 proteinFUSIP1 proteinFUSIP2 proteinSFRS13A proteinTASR protein |
Information sourced from Uniprot.org