| Post Translational Modifications | Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock. |
| Function | Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing. May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 1040 Kda Sr-Repressor ProteinSrrp40Fus-Interacting Serine-Arginine-Rich Protein 1Splicing Factor Srp38Splicing Factor - Arginine/Serine-Rich 13aTls-Associated Protein With Ser-Arg RepeatsTasrTls-Associated Protein With Sr RepeatsTls-Associated Serine-Arginine ProteinTls-Associated Sr Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Protein Names | Serine/Arginine-Rich Splicing Factor 10 protein40 Kda Sr-Repressor Protein proteinSrrp40 proteinFus-Interacting Serine-Arginine-Rich Protein 1 proteinSplicing Factor Srp38 proteinSplicing Factor - Arginine/Serine-Rich 13a proteinTls-Associated Protein With Ser-Arg Repeats proteinTasr proteinTls-Associated Protein With Sr Repeats proteinTls-Associated Serine-Arginine Protein proteinTls-Associated Sr Protein proteinSRSF10 proteinFUSIP1 proteinFUSIP2 proteinSFRS13A proteinTASR protein |
Information sourced from Uniprot.org
