Human SRR protein (Recombinant) (His-Tag) (STJP017492)

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STJP017492
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Short Description :Recombinant-Human SRR-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SRR
Gene ID:63826
Uniprot ID:SRR_HUMAN
Accession Number:NP_068766
Immunogen:Human
Immunogen Region:1-340aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMCAQYC ISFADVEKAH INIRDSIHLT PVLTSSILNQ LTGRNLFFKC ELFQKTGSFK IRGALNAVRS LVPDALERKP KAVVTHSSGN HGQALTYAAK LEGIPAYIVV PQTAPDCKKL AIQAYGASIV YCEPSDESRE NVAKRVTEET EGIMVHPNQE PAVIAGQGTI ALEVLNQVPL VDALVVPVGG GGMLAGIAIT VKALKPSV
Tissue Specificity Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney, and liver.
Post Translational Modifications S-nitrosylated, leading to decrease the enzyme activity.
Function Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
Protein Name Serine Racemase
D-Serine Ammonia-Lyase
D-Serine Dehydratase
L-Serine Ammonia-Lyase
L-Serine Dehydratase
Database Links Reactome: R-HSA-977347
Cellular Localisation
Alternative Protein Names Serine Racemase protein
D-Serine Ammonia-Lyase protein
D-Serine Dehydratase protein
L-Serine Ammonia-Lyase protein
L-Serine Dehydratase protein
SRR protein

Information sourced from Uniprot.org

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