Human SRGN protein (Recombinant) (N-His) (STJP015418)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SRGN-N-His protein was developed from mammalian cells for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SRGN |
| Gene ID | 5552 |
| Uniprot ID | SRGN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly27-Leu158 |
Additional Info
| Function | Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization. |
| Protein Name | SerglycinHematopoietic Proteoglycan Core ProteinPlatelet Proteoglycan Core ProteinP.pgSecretory Granule Proteoglycan Core Protein |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | Cytoplasmic GranuleCytolytic GranuleSecretedExtracellular SpaceGolgi ApparatusFound In Mast Cell Granules And In Cytoplasmic Granules Of Cytolytic T Lymphocytes From Where It Is Secreted Upon Cell ActivationSecreted Constitutively By Endothelial Cells And MacrophagesLocated To Golgi Apparatus During Neutrophil Differentiation |
| Alternative Protein Names | Serglycin proteinHematopoietic Proteoglycan Core Protein proteinPlatelet Proteoglycan Core Protein proteinP.pg proteinSecretory Granule Proteoglycan Core Protein proteinSRGN proteinPRG proteinPRG1 protein |
Information sourced from Uniprot.org