| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g |
| Gene Symbol: | CD36 |
| Gene ID: | 948 |
| Uniprot ID: | CD36_HUMAN |
| Immunogen Region: | Gly30-Asn439 |
| Immunogen: | Recombinant Human SR-B3/CD36 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly30-Asn439) of human CD36 (Accession #P16671) fused with an hFc tag at the N-terminus. |
| Immunogen Sequence: | GDLLIQKTIKKQVVLEEGTI AFKNWVKTGTEVYRQFWIFD VQNPQEVMMNSSNIQVKQRG PYTYRVRFLAKENVTQDAED NTVSFLQPNGAIFEPSLSVG TEADNFTVLNLAVAAASHIY QNQFVQMILNSLINKSKSSM FQVRTLRELLWGYRDPFLSL VPYPVTTTVGLFYPYNNTAD GVYKVFNGKDNISKVAIIDT YKGKRNLSYWESHCDMINGT DAASFPPFVEKSQVLQFFS |
| Function | Multifunctional glycoprotein that acts as a receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption. Mechanistically, binding of fatty acids activates downstream kinase LYN, which phosphorylates the palmitoyltransferase ZDHHC5 and inactivates it, resulting in the subsequent depalmitoylation of CD36 and caveolar endocytosis. In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway. Involved in oral fat perception and preferences. Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract. Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis. Receptor for thrombospondins, THBS1 and THBS2, mediating their antiangiogenic effects. Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting together with THBS1. As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling. |
| Protein Name | Platelet Glycoprotein 4 Fatty Acid Translocase Fat Glycoprotein Iiib Gpiiib Leukocyte Differentiation Antigen Cd36 Pas Iv Pas-4 Platelet Collagen Receptor Platelet Glycoprotein Iv Gpiv Thrombospondin Receptor Cd Antigen Cd36 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-1236973 Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-168188 Reactome: R-HSA-1989781 Reactome: R-HSA-3000471 Reactome: R-HSA-381340 Reactome: R-HSA-434313 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Membrane Raft Golgi Apparatus Apical Cell Membrane Upon Ligand-Binding Internalized Through Dynamin-Dependent Endocytosis |
| Alternative Protein Names | Platelet Glycoprotein 4 protein Fatty Acid Translocase protein Fat protein Glycoprotein Iiib protein Gpiiib protein Leukocyte Differentiation Antigen Cd36 protein Pas Iv protein Pas-4 protein Platelet Collagen Receptor protein Platelet Glycoprotein Iv protein Gpiv protein Thrombospondin Receptor protein Cd Antigen Cd36 protein CD36 protein GP3B protein GP4 protein |
Information sourced from Uniprot.org