Human SPINK5 protein (Recombinant) (N-His) (STJP006061)

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STJP006061
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SPINK5-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SPINK5
Gene ID: 11005
Uniprot ID: ISK5_HUMAN
Immunogen Region: Gly699-Ser976
Immunogen: Homo sapiens (Human)
Post Translational Modifications Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases.
Function Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Protein Name Serine Protease Inhibitor Kazal-Type 5
Lympho-Epithelial Kazal-Type-Related Inhibitor
Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665
Database Links Reactome: R-HSA-6809371
Reactome: R-HSA-9725554
Cellular Localisation Secreted
Alternative Protein Names Serine Protease Inhibitor Kazal-Type 5 protein
Lympho-Epithelial Kazal-Type-Related Inhibitor protein
Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 protein
SPINK5 protein

Information sourced from Uniprot.org

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