Human SP7 protein (Recombinant) (N-His) (STJP005744)

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STJP005744
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SP7-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SP7
Gene ID: 121340
Uniprot ID: SP7_HUMAN
Immunogen Region: Ser370-Ile431
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts.
Function Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences.
Protein Name Transcription Factor Sp7
Zinc Finger Protein Osterix
Database Links Reactome: R-HSA-8940973
Cellular Localisation Nucleus
Alternative Protein Names Transcription Factor Sp7 protein
Zinc Finger Protein Osterix protein
SP7 protein
OSX protein

Information sourced from Uniprot.org