| Host: | HEK293 |
| Note: | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SOST/Sclerostin-N-His-Avi protein was developed from hek293 and has a target region of N-His-Avi. For use in research applications. |
| Conjugation: | Biotin |
| Formulation: | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Dilution Range: | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Storage Instruction: | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin: | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
| Gene Symbol: | SOST |
| Gene ID: | 50964 |
| Uniprot ID: | SOST_HUMAN |
| Immunogen Region: | Gln24-Tyr213 |
| Immunogen: | DNA sequence encoding Human SOST/Sclerostin including a N-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681 Reactome: R-HSA-3772470 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Protein Names | Sclerostin protein SOST protein UNQ2976 protein PRO7455 protein PRO7476 protein |
Information sourced from Uniprot.org