Human SORBS3 protein (Recombinant) (His-Tag) (STJP018604)

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STJP018604
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SORBS3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: SORBS3
Gene ID: 10174
Uniprot ID: VINEX_HUMAN
Immunogen Region: 1-329aa
Accession Number: NP_001018003
Immunogen: Human
Immunogen Sequence: MADGGSP FLGRRDFVYP SSTRDPSASN GGGSPARREE KKRKAARLKF DFQAQSPKEL TLQKGDIVYI HKEVDKNWLE GEHHGRLGIF PANYVEVLPA DEIPKPIKPP TYQVLEYGEA VAQYTFKGDL EVELSFRKGE HICLIRKVNE NWYEGRITGT GRQGIFPASY VQVSREPRLR LCDDGPQLPT SPRLTAAARS ARHPSS
Tissue Specificity Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Post Translational Modifications Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
Function Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Protein Name Vinexin
Sh3-Containing Adapter Molecule 1
Scam-1
Sorbin And Sh3 Domain-Containing Protein 3
Database Links Reactome: R-HSA-445355
Cellular Localisation Isoform Alpha: Cell Junction
Cytoplasm
Cytoskeleton
Localized At Cell-Extracellular Matrix Junctions
Both Isoforms Were Localized At Focal Adhesion And Cell-Cell Adhesion Sites
Isoform Beta: Cell Junction
Nucleus
Vinexin Beta Was Also Found In The Nucleus
Alternative Protein Names Vinexin protein
Sh3-Containing Adapter Molecule 1 protein
Scam-1 protein
Sorbin And Sh3 Domain-Containing Protein 3 protein
SORBS3 protein
SCAM1 protein

Information sourced from Uniprot.org

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