Human SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit (STJE0012259)
SPECIFICATIONS
General Information
| Short Description | This SOCS2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.059ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | SOCS2 |
| Gene ID | 8835 |
| Uniprot ID | SOCS2_HUMAN |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes. |
| Post Translational Modifications | Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC. Ubiquitination is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. |
| Protein Name | Suppressor Of Cytokine Signaling 2Socs-2Cytokine-Inducible Sh2 Protein 2Cis-2Stat-Induced Stat Inhibitor 2Ssi-2 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-8951664Reactome: R-HSA-9706369Reactome: R-HSA-982772 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Suppressor Of Cytokine Signaling 2 ELISA kitSocs-2 ELISA kitCytokine-Inducible Sh2 Protein 2 ELISA kitCis-2 ELISA kitStat-Induced Stat Inhibitor 2 ELISA kitSsi-2 ELISA kitSOCS2 ELISA kitCIS2 ELISA kitSSI2 ELISA kitSTATI2 ELISA kit |
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Information sourced from Uniprot.org