| Post Translational Modifications | Polyubiquitinated by AMFR/gp78 at Cys-277, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-277 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. Oxidized at Cys-277: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-277, preventing ubiquitination at the same site, and resulting in protein stabilization. |
| Function | Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. Isoform 2: Has lower enzymatic activity compared to isoform 1. Isoform 3: Has lower enzymatic activity compared to isoform 1. |
| Protein Name | Sterol O-Acyltransferase 2Acyl-Coenzyme A -Cholesterol Acyltransferase 2Acat-2Cholesterol Acyltransferase 2 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Sterol O-Acyltransferase 2 proteinAcyl-Coenzyme A -Cholesterol Acyltransferase 2 proteinAcat-2 proteinCholesterol Acyltransferase 2 proteinSOAT2 proteinACACT2 proteinACAT2 protein |
Information sourced from Uniprot.org
