Human SNAPIN protein (Recombinant) (N-His) (STJP007596)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SNAPIN-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SNAPIN |
| Gene ID | 23557 |
| Uniprot ID | SNAPN_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly21-Lys136 |
Additional Info
| Post Translational Modifications | Phosphorylated by CSNK1D/CK1. Phosphorylated by PKD, phosphorylation controls SNAPIN protein stability. |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. |
| Protein Name | Snare-Associated Protein SnapinBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7Bloc-1 Subunit 7Synaptosomal-Associated Protein 25-Binding ProteinSnap-Associated Protein |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytosolPerinuclear RegionGolgi Apparatus MembraneLysosome MembraneCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneColocalizes With Nanos1 And Pum2 In The Perinuclear Region Of Germ Cells |
| Alternative Protein Names | Snare-Associated Protein Snapin proteinBiogenesis Of Lysosome-Related Organelles Complex 1 Subunit 7 proteinBloc-1 Subunit 7 proteinSynaptosomal-Associated Protein 25-Binding Protein proteinSnap-Associated Protein proteinSNAPIN proteinBLOC1S7 proteinSNAP25BP proteinSNAPAP protein |
Information sourced from Uniprot.org