| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Protein Name | Spermine OxidasePolyamine Oxidase 1Pao-1Paoh1 |
| Database Links | Reactome: R-HSA-141334 Q9NWM0-3Reactome: R-HSA-351200 Q9NWM0-3 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 4: CytoplasmIsoform 6: Cytoplasm |
| Alternative Protein Names | Spermine Oxidase proteinPolyamine Oxidase 1 proteinPao-1 proteinPaoh1 proteinSMOX proteinC20orf16 proteinSMO proteinUNQ3039 proteinPRO9854 protein |
Information sourced from Uniprot.org