Human SMC1A protein (Recombinant) (N-His) (STJP011287)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SMC1A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SMC1A |
| Gene ID | 8243 |
| Uniprot ID | SMC1A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ile489-Asp667 |
Additional Info
| Function | Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 1aSmc Protein 1aSmc-1-AlphaSmc-1aSb1.8 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreAssociates With ChromatinBefore Prophase It Is Scattered Along Chromosome ArmsDuring ProphaseMost Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By PlkExcept At CentromeresWhere Cohesin Complexes RemainAt AnaphaseThe Rad21 Subunit Of The Cohesin Complex Is CleavedLeading To The Dissociation Of The Complex From ChromosomesAllowing Chromosome SeparationIn Germ CellsCohesin Complex Dissociates From Chromatin At Prophase IAnd May Be Replaced By A Meiosis-Specific Cohesin ComplexThe Phosphorylated Form On Ser-957 And Ser-966 Associates With Chromatin During G1/S/G2 Phases But Not During M PhaseSuggesting That Phosphorylation Does Not Regulate Cohesin FunctionIntegral Component Of The Functional Centromere-Kinetochore Complex At The Kinetochore Region During Mitosis |
| Alternative Protein Names | Structural Maintenance Of Chromosomes Protein 1a proteinSmc Protein 1a proteinSmc-1-Alpha proteinSmc-1a proteinSb1.8 proteinSMC1A proteinDXS423E proteinKIAA0178 proteinSB1.8 proteinSMC1 proteinSMC1L1 protein |
Information sourced from Uniprot.org