Human SMC1A protein (Recombinant) (N-His) (STJP011287)

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STJP011287
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SMC1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SMC1A
Gene ID: 8243
Uniprot ID: SMC1A_HUMAN
Immunogen Region: Ile489-Asp667
Immunogen: Homo sapiens (Human)
Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Protein Name Structural Maintenance Of Chromosomes Protein 1a
Smc Protein 1a
Smc-1-Alpha
Smc-1a
Sb1.8
Database Links Reactome: R-HSA-1221632
Reactome: R-HSA-2467813
Reactome: R-HSA-2468052
Reactome: R-HSA-2470946
Reactome: R-HSA-2500257
Reactome: R-HSA-3108214
Reactome: R-HSA-9018519
Cellular Localisation Nucleus
Chromosome
Centromere
Kinetochore
Associates With Chromatin
Before Prophase It Is Scattered Along Chromosome Arms
During Prophase
Most Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk
Except At Centromeres
Where Cohesin Complexes Remain
At Anaphase
The Rad21 Subunit Of The Cohesin Complex Is Cleaved
Leading To The Dissociation Of The Complex From Chromosomes
Allowing Chromosome Separation
In Germ Cells
Cohesin Complex Dissociates From Chromatin At Prophase I
And May Be Replaced By A Meiosis-Specific Cohesin Complex
The Phosphorylated Form On Ser-957 And Ser-966 Associates With Chromatin During G1/S/G2 Phases But Not During M Phase
Suggesting That Phosphorylation Does Not Regulate Cohesin Function
Integral Component Of The Functional Centromere-Kinetochore Complex At The Kinetochore Region During Mitosis
Alternative Protein Names Structural Maintenance Of Chromosomes Protein 1a protein
Smc Protein 1a protein
Smc-1-Alpha protein
Smc-1a protein
Sb1.8 protein
SMC1A protein
DXS423E protein
KIAA0178 protein
SB1.8 protein
SMC1 protein
SMC1L1 protein

Information sourced from Uniprot.org