Human SLC8A1 protein (Recombinant) (N-His) (STJP007833)

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STJP007833
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC8A1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC8A1
Gene ID: 6546
Uniprot ID: NAC1_HUMAN
Immunogen Region: Ser407-Glu718
Immunogen: Homo sapiens (Human)
Function Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Protein Name Sodium/Calcium Exchanger 1
Na(+/Ca(2+-Exchange Protein 1
Solute Carrier Family 8 Member 1
Database Links Reactome: R-HSA-418359
Reactome: R-HSA-425561
Reactome: R-HSA-5578775
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Protein Names Sodium/Calcium Exchanger 1 protein
Na(+/Ca(2+-Exchange Protein 1 protein
Solute Carrier Family 8 Member 1 protein
SLC8A1 protein
CNC protein
NCX1 protein

Information sourced from Uniprot.org

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