Human SLC7A5 protein (Recombinant) (N-GST & C-His) (STJP016098)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC7A5-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | SLC7A5 |
| Gene ID | 8140 |
| Uniprot ID | LAT1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Val148-Glu169&Gly215-Asn242&Thr298-Ser324&Lys479-Thr507 |
Additional Info
| Function | The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier. Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane. When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane. (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. |
| Protein Name | Large Neutral Amino Acids Transporter Small Subunit 14f2 Light Chain4f2 Lc4f2lcCd98 Light ChainIntegral Membrane Protein E16E16L-Type Amino Acid Transporter 1Hlat1Solute Carrier Family 7 Member 5Y+ System Cationic Amino Acid Transporter |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230Reactome: R-HSA-71240 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneLysosome MembraneLocated To The Plasma Membrane By Slc3a2/4f2hcLocalized To The Apical Membrane Of Placental Syncytiotrophoblastic CellsRecruited To Lysosomes By Laptm4b |
| Alternative Protein Names | Large Neutral Amino Acids Transporter Small Subunit 1 protein4f2 Light Chain protein4f2 Lc protein4f2lc proteinCd98 Light Chain proteinIntegral Membrane Protein E16 proteinE16 proteinL-Type Amino Acid Transporter 1 proteinHlat1 proteinSolute Carrier Family 7 Member 5 proteinY+ System Cationic Amino Acid Transporter proteinSLC7A5 proteinCD98LC proteinLAT1 proteinMPE16 protein |
Information sourced from Uniprot.org