Human SLC5A8 protein (Recombinant) (N-GST & C-His) (STJP008830)

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STJP008830
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC5A8-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC5A8
Gene ID: 160728
Uniprot ID: SC5A8_HUMAN
Immunogen Region: Ala460-Ser520
Immunogen: Homo sapiens (Human)
Function Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons. Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced.
Protein Name Sodium-Coupled Monocarboxylate Transporter 1
Apical Iodide Transporter
Electrogenic Sodium Monocarboxylate Cotransporter
Sodium Iodide-Related Cotransporter
Solute Carrier Family 5 Member 8
Database Links Reactome: R-HSA-197264
Reactome: R-HSA-428643
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Expressed At The Apical Membrane Of Normal Tall Thyrocytes And Of Colonic Epithelial Cells
Alternative Protein Names Sodium-Coupled Monocarboxylate Transporter 1 protein
Apical Iodide Transporter protein
Electrogenic Sodium Monocarboxylate Cotransporter protein
Sodium Iodide-Related Cotransporter protein
Solute Carrier Family 5 Member 8 protein
SLC5A8 protein
AIT protein
SMCT protein
SMCT1 protein

Information sourced from Uniprot.org

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