Human SLC5A1/NAGT protein (Recombinant) (N-His) (STJP014415)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC5A1/NAGT-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | SLC5A1 |
| Gene ID | 6523 |
| Uniprot ID | SC5A1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | [Asp230-Pro277] & [Ser335-Gly380] & [Arg564-Thr643] |
Additional Info
| Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
| Protein Name | Sodium/Glucose Cotransporter 1Na(+/Glucose Cotransporter 1High Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 1 |
| Database Links | Reactome: R-HSA-189200Reactome: R-HSA-5656364Reactome: R-HSA-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Sodium/Glucose Cotransporter 1 proteinNa(+/Glucose Cotransporter 1 proteinHigh Affinity Sodium-Glucose Cotransporter proteinSolute Carrier Family 5 Member 1 proteinSLC5A1 proteinNAGT proteinSGLT1 protein |
Information sourced from Uniprot.org