| Function | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells. Isoform 6: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. |
| Protein Name | Sodium Bicarbonate Cotransporter 3Electroneutral Na/Hco(3 CotransporterSodium Bicarbonate Cotransporter 2Sodium Bicarbonate Cotransporter 2bBicarbonate TransporterSolute Carrier Family 4 Member 7 |
| Database Links | Reactome: R-HSA-425381Reactome: R-HSA-9013405Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9035034 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCell ProjectionStereociliumCell MembraneLocalizes To The Stereocilia Of Cochlear Outer Hair Cells And To The Lateral Membrane Of Cochlear Inner Hair CellsIsoform 6: Cell Membrane |
| Alternative Protein Names | Sodium Bicarbonate Cotransporter 3 proteinElectroneutral Na/Hco(3 Cotransporter proteinSodium Bicarbonate Cotransporter 2 proteinSodium Bicarbonate Cotransporter 2b proteinBicarbonate Transporter proteinSolute Carrier Family 4 Member 7 proteinSLC4A7 proteinBT proteinNBC2 proteinNBC2B proteinNBC3 proteinNBCn1 proteinSBC2 proteinSLC4A6 protein |
Information sourced from Uniprot.org
