Human SLC4A4 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007452)

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STJP007452
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC4A4-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC4A4
Gene ID: 8671
Uniprot ID: S4A4_HUMAN
Immunogen Region: Pro106-Ser233
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase.phosphorylation seems to inhibit SLC4A4 activity. N-glycosylated. May not be necessary for the transporter basic functions.
Function Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Protein Name Electrogenic Sodium Bicarbonate Cotransporter 1
Sodium Bicarbonate Cotransporter
Na(+/Hco3(- Cotransporter
Solute Carrier Family 4 Member 4
Knbc1
Database Links Reactome: R-HSA-425381
Reactome: R-HSA-5619054
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Alternative Protein Names Electrogenic Sodium Bicarbonate Cotransporter 1 protein
Sodium Bicarbonate Cotransporter protein
Na(+/Hco3(- Cotransporter protein
Solute Carrier Family 4 Member 4 protein
Knbc1 protein
SLC4A4 protein
NBC protein
NBC1 protein
NBCE1 protein

Information sourced from Uniprot.org

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