| Post Translational Modifications | Methylated at His-375 by METTL9. N-Glycosylated. |
| Function | Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable. In addition, is also a high affinity copper transporter in vitro. Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development. |
| Protein Name | Zinc Transporter Zip5Solute Carrier Family 39 Member 5Zrt- And Irt-Like Protein 5Zip-5 |
| Database Links | Reactome: R-HSA-442380 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinLocalized To The Basolateral Surfaces Of EnterocytesPancreatic Acinar And Endoderm CellsDuring Zinc Deficiency DietThe Basolateral Cell Membrane Localization Is Lost In The IntestineThe Visceral Yolk Sac And Acinar CellDuring Zinc RepletionIs Relocalized To The Basolateral Membrane Of EnterocytesVisceral Endoderm Cells And Pancreatic Acinar CellsZinc Can Regulate The Turnover Of Protein At The MembraneDuring Zinc DeficiencyIs Internalized And Degraded In EnterocytesAcinar Cells And Endoderm CellsEndocytosed Through The Endolysosomal Degradation Pathway Rab5a Pathway |
| Alternative Protein Names | Zinc Transporter Zip5 proteinSolute Carrier Family 39 Member 5 proteinZrt- And Irt-Like Protein 5 proteinZip-5 proteinSLC39A5 proteinZIP5 protein |
Information sourced from Uniprot.org
