Tissue Specificity | In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons.much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive. |
Post Translational Modifications | |
Function | Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. |
Protein Name | Proton-Coupled Zinc Antiporter Slc30a8Solute Carrier Family 30 Member 8Zinc Transporter 8Znt-8 |
Database Links | Reactome: R-HSA-264876Reactome: R-HSA-435368 |
Cellular Localisation | Cytoplasmic VesicleSecretory Vesicle MembraneMulti-Pass Membrane ProteinCell MembraneAssociated With Insulin And Glucagon Secretory Granules |
Alternative ELISA Names | Proton-Coupled Zinc Antiporter Slc30a8 ELISA kitSolute Carrier Family 30 Member 8 ELISA kitZinc Transporter 8 ELISA kitZnt-8 ELISA kitSLC30A8 ELISA kitZNT8 ELISA kit |
output | |
Information sourced from Uniprot.org