Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. |
Protein Name | Electrogenic Aspartate/Glutamate Antiporter Slc25a12 - MitochondrialAraceli HiperlargaAralarAralar1Mitochondrial Aspartate Glutamate Carrier 1Solute Carrier Family 25 Member 12 |
Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
Alternative Protein Names | Electrogenic Aspartate/Glutamate Antiporter Slc25a12 - Mitochondrial proteinAraceli Hiperlarga proteinAralar proteinAralar1 proteinMitochondrial Aspartate Glutamate Carrier 1 proteinSolute Carrier Family 25 Member 12 proteinSLC25A12 proteinAGC1 proteinARALAR1 protein |
Information sourced from Uniprot.org