Human SLC22A5 protein (Recombinant) (N-His-SUMO) (STJP007914)

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STJP007914
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC22A5-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC22A5
Gene ID: 6584
Uniprot ID: S22A5_HUMAN
Immunogen Region: Thr45-Lys141
Immunogen: Homo sapiens (Human)
Post Translational Modifications Glycosylated. Glycosylation affects the expression levels. Isoform 3: Not glycosylated.
Function Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3. In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Isoform 3: Retained in the ER, unable to perform carnitine uptake.
Protein Name Organic Cation/Carnitine Transporter 2
High-Affinity Sodium-Dependent Carnitine Cotransporter
Solute Carrier Family 22 Member 5
Database Links Reactome: R-HSA-200425
Reactome: R-HSA-549127
Reactome: R-HSA-5619053
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Basal Cell Membrane
In Intestinal Cells
Apical Expression Is Induced By Tnf
Localized To The Basal Membrane Of Sertoli Cells
Isoform 3: Endoplasmic Reticulum
Alternative Protein Names Organic Cation/Carnitine Transporter 2 protein
High-Affinity Sodium-Dependent Carnitine Cotransporter protein
Solute Carrier Family 22 Member 5 protein
SLC22A5 protein
OCTN2 protein

Information sourced from Uniprot.org

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