| Function | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity. |
| Protein Name | Reduced Folate TransporterFoltCyclic Dinucleotide -Anion Antiporter Slc19a1Folate -Anion Antiporter Slc19a1Intestinal Folate Carrier 1Ifc-1Placental Folate TransporterReduced Folate Carrier ProteinRfcHrfcReduced Folate Transporter 1Rft-1Solute Carrier Family 19 Member 1Hslc19a1 |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell Membrane |
| Alternative Protein Names | Reduced Folate Transporter proteinFolt proteinCyclic Dinucleotide -Anion Antiporter Slc19a1 proteinFolate -Anion Antiporter Slc19a1 proteinIntestinal Folate Carrier 1 proteinIfc-1 proteinPlacental Folate Transporter proteinReduced Folate Carrier Protein proteinRfc proteinHrfc proteinReduced Folate Transporter 1 proteinRft-1 proteinSolute Carrier Family 19 Member 1 proteinHslc19a1 proteinSLC19A1 proteinFLOT1 proteinRFC1 protein |
Information sourced from Uniprot.org
